| Thermodynamic evaluation of the effect of Cu2+ ion on the interaction of Ribavirin drug with BSA |
| کد مقاله : 1116-PHYCHEM23 |
| نویسندگان |
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صبا حدیدی * دانشگاه رازی، دانشکده شیمی، گروه شیمی معدنی، کرمانشاه، ایران |
| چکیده مقاله |
| In this study, the effect of Cu2+ ion on the interaction between bovine serum albumin (BSA) and Ribavirin drug (Rib) was investigated by fluorescence spectroscopy. The negative sign of free energy (ΔG) confirmed that Rib-BSA reaction is spontaneous both in the absence and presence of Cu2+ ions. The positive values for ΔH and ΔS indicated that hydrophobic interactions play major roles in Rib-BSA association in the absence of Cu2+ ion, while in the presence of Cu2+ ion, it is the electrostatic interaction that play essential role in the binding process. |
| کلیدواژه ها |
| Thermodynamic parameters; Ribavirin drug; BSA interaction; Copper ion; Hydrophobic interaction; Electrostatic force. |
| وضعیت: پذیرفته شده برای ارسال فایل های ارائه پوستر |