| Effect of Cα -methylated residue on the folding behavior of p53 peptide: A Molecular Dynamics Study |
| کد مقاله : 1181-PHYCHEM23 |
| نویسندگان |
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الهام ضرورتی *، سیف اله جلیلی دانشگاه خواجه نصیرالدین طوسی |
| چکیده مقاله |
| One of the cancer- associated protein -protein interactions is the Hdm2-p53 complex. Over expression of Hdm2 disrupts the normal activity of p53. Disruption of the HDM2-p53 interaction to maintain p53 function is considered a therapeutic approach to cancer treatment. To inhibit unnatural PPIs, researchers are always look for strategies that interfere with these interactions. Among unnatural-backbone units for increase the helical content of peptides in the α- helix secondary structure, chiral Cα-Me-α-residues was compared to mimic the helical domain of the p53 protein .Helix mimetics containing Cα-methylated residues can be a good inhibitor for P53-Hdm2 interaction. |
| کلیدواژه ها |
| P53; Cα-Me-α-residue; Molecular dynamics simulations |
| وضعیت: پذیرفته شده برای ارسال فایل های ارائه پوستر |