| Anticancer drug imatinib/β-cyclodextrin inclusion complex to enhance solubility and bioavailability: Molecular modeling studies |
| کد مقاله : 1188-PHYCHEM23 |
| نویسندگان |
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نینا علیزاده *1، متین کارپور2 1گروه شیمی دانشکده علوم دانشگاه گیلان 2گروه آموزشی شیمی پردیس دانشگاه گیلان |
| چکیده مقاله |
| Host-guest interactions in various protonation forms of the anticancer drug imatinib (IMA)with beta-cyclodextrin (CD) have been investigated using techniques of 1H NMR, phase solubility, FT-IR, XRD, SEM and dissolution study in vitro. The solubility and dissolution rate of IMA were significantly improved upon complexation with βCD as compared to IMA alone. Phase-solubility analysis showed A(L)-type diagram with beta-CD, which suggested the formation of 1:1 inclusion complexes. Molecular modeling further supported the inclusion complex formation. The entry of the Imatinib molecule into the beta-cyclodextrin cavity from both ends was exothermic reaction. |
| کلیدواژه ها |
| Inclusion complex, β-Cyclodextrin, Stability constant, Imatinib, Molecular modeling |
| وضعیت: پذیرفته شده برای ارسال فایل های ارائه پوستر |